G-quadruplex-forming aptamer enhances the peroxidase activity of myoglobin against luminol
نویسندگان
چکیده
منابع مشابه
Backbone modification promotes peroxidase activity of G-quadruplex-based DNAzyme.
In this work we studied how backbone chemical modifications, such as 2'-O-methyl, phosphorothioate, L-form nucleotides and locked nucleic acid, on G-quadruplex based DNAzymes would affect their peroxidase activity. Our results indicate that 2'-O-methyl modification facilitates the formation of a perfectly compacted parallel structure and significantly promotes peroxidase activity of G-quadruple...
متن کاملThe G-quadruplex-forming aptamer AS1411 potently inhibits HIV-1 attachment to the host cell
AS1411 is a G-rich aptamer that forms a stable G-quadruplex structure and displays antineoplastic properties both in vitro and in vivo. This oligonucleotide has undergone phase 2 clinical trials. The major molecular target of AS1411 is nucleolin (NCL), a multifunctional nucleolar protein also present in the cell membrane where it selectively mediates the binding and uptake of AS1411. Cell-surfa...
متن کاملErratum: General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter
This is a correction to the following paper: General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter, Bo Liu, Da Li* and Hong Shang*, Chemistry Central Journal 2014, 8:43 (1 July 2014). CorrectionThis is a correction to the following paper: Generalperoxidase activity of a parallel G-quadruplex-h...
متن کاملGeneral peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter
BACKGROUND A 39-base-pair sequence (Pu39WT) located 58 to 19 base pairs upstream of the Bcl-2 P1 promoter has been implicated in the formation of an intramolecular mixed G-quadruplex structure and is believed to play a major role in the regulation of bcl-2 transcription. However, an extensive functional exploration requires further investigation. To further exploit the structure-function relati...
متن کاملDiscovery of novel anti-HIV active G-quadruplex-forming oligonucleotides.
A series of d((5')TGGGAG(3')) sequences, 5'-conjugated with a variety of aromatic groups through phosphodiester linkages, were synthesized, showing CD spectra diagnostic of parallel-stranded, tetramolecular G-quadruplex structures. When tested for anti-HIV-1 and HIV-2 activity, potent inhibition of HIV-1 infection in CEM cell cultures was found, associated with high selectivity index values. Su...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2021
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkab388